Ageing through an evolutionary, transdisciplinary, lens.

Evolutionary conservation of hindbrain segmentation in vertebrates. On pages 526–538 of this issue, Parker et al. explore the origin and diversifi cation of the Hox gene regulatory network for vertebrate hindbrain segmentation and patterning. The cover depicts transgenic embryos of three different species – sea lamprey, mouse and zebrafi sh – expressing fl uorescent proteins in the developing hindbrain through the activity of segmentspecifi c cis-regulatory elements. Segmental enhancers from mouse and zebrafi sh can function when introduced into lamprey, highlighting the conservation of this gene regulatory network to the vertebrate base. Photo credits: Hugo Parker and Mark Parrish. Illustration: Mark Miller. Cover Photograph Regulation of cytoplasmic dynein by anchor proteins